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Three things, per the article: individual tolerability, the patient's metabolic goals, and whether side effects justify holding at a lower effective level rather than pushing toward the maximum

It was constant, overwhelming and I gained over seven pounds in that short period

These divergent findings likely reflect heterogeneity in study design, mechanisms of action of the drugs evaluated, duration of follow-up, and the degree of metabolic phenotyping across populations

Liu Y, Liu Q, Wang X et al (2018) Inhibition of autophagy attenuated ethylene glycol induced crystals deposition and renal injury in a rat model of nephrolithiasis

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